- The first significant change to the administration since January 2017 was announced by President Akufo-Addo on February 14. Along with the removal of Roads Minister Kwame Amoako-Atta and Health Minister Kwaku Agyemang Manu, Finance Minister Ken Ofori-Atta was also stripped of his duties. New faces were assigned to various ministries while other ministers, including deputy ministers, resigned.
- Kwaku Afriyie was replaced as Minister-designate for the Environment, Science, Technology, and Innovation by Ophelia Mensah Hayford. Following the passing of her spouse, the former police officer entered politics. She has experience working as a police advisor for the UN and with the Interpol Unit at the CID Headquarters.
- Dakoa Newman joined the Public Accounts and Education Committees of Parliament after being named Minister-designate for Gender, Children, and Social Protection. Her master’s degree in program and project management is from the University of Warwick in the United Kingdom, and her bachelor’s degree in political science is from the University of Ghana, Legon.
- Following the death of Mr. Emmanuel Boakye Agyarko, a by-election was held to elect Lydia Seyram Alhassan as the next Member of Parliament for Ayawaso West Wuogon. She was named as the Minister-designate for Sanitation and Water Resources. She graduated with a Bachelor of Administration from Ghana’s Institute of Management and Public Administration (GIMPA) and an MBA in Marketing from the University of Ghana Business School, Legon.
- Daniel Machator, the second disabled person to be appointed as a minister in Ghana, took Joshua Gmayenaam Makubu’s position as Oti Regional Minister-designate. Dan Botwe’s position as Deputy Minister for Local Government and Rural Development was filled by Vincent Ekow Assafuah. Henry Quarter, the Member of Parliament for Ayawaso Central, was replaced as the Greater Accra Regional Minister-designate by Titus Glover. Deputy Minister-designate for Information Sylvester Tetteh replaced Fatima Abubakar, who was named vice chair of the communications committee of parliament.